학술논문
Recruitment of pre-dementia participants: main enrollment barriers in a longitudinal amyloid-PET study
Document Type
article
Author
Ilse Bader; Ilona Bader; Isadora Lopes Alves; David Vállez García; Bruno Vellas; Bruno Dubois; Mercè Boada; Marta Marquié; Daniele Altomare; Philip Scheltens; Rik Vandenberghe; Bernard Hanseeuw; Michael Schöll; Giovanni B. Frisoni; Frank Jessen; Agneta Nordberg; Miia Kivipelto; Craig W. Ritchie; Oriol Grau-Rivera; José Luis Molinuevo; Lisa Ford; Andrew Stephens; Rossella Gismondi; Juan Domingo Gispert; Gill Farrar; Frederik Barkhof; Pieter Jelle Visser; Lyduine E. Collij; on behalf of the AMYPAD consortium
Source
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-14 (2023)
Subject
Language
English
ISSN
1758-9193
Abstract
Abstract Background The mismatch between the limited availability versus the high demand of participants who are in the pre-dementia phase of Alzheimer’s disease (AD) is a bottleneck for clinical studies in AD. Nevertheless, potential enrollment barriers in the pre-dementia population are relatively under-reported. In a large European longitudinal biomarker study (the AMYPAD-PNHS), we investigated main enrollment barriers in individuals with no or mild symptoms recruited from research and clinical parent cohorts (PCs) of ongoing observational studies. Methods Logistic regression was used to predict study refusal based on sex, age, education, global cognition (MMSE), family history of dementia, and number of prior study visits. Study refusal rates and categorized enrollment barriers were compared between PCs using chi-squared tests. Results 535/1856 (28.8%) of the participants recruited from ongoing studies declined participation in the AMYPAD-PNHS. Only for participants recruited from clinical PCs (n = 243), a higher MMSE-score (β = − 0.22, OR = 0.80, p