학술논문
A multicenter cross-sectional French study of the impact of COVID-19 on neuromuscular diseases
Document Type
article
Author
Lucie Isoline Pisella; Sara Fernandes; Guilhem Solé; Tanya Stojkovic; Céline Tard; Jean-Baptiste Chanson; Françoise Bouhour; Emmanuelle Salort-Campana; Guillemette Beaudonnet; Louise Debergé; Fanny Duval; Aude-Marie Grapperon; Marion Masingue; Aleksandra Nadaj-Pakleza; Yann Péréon; Frédérique Audic; Anthony Behin; Diane Friedman; Armelle Magot; Jean-Baptiste Noury; Sarah Souvannanorath; Karim Wahbi; Jean-Christophe Antoine; Kévin Bigaut; Jean-Philippe Camdessanché; Pascal Cintas; Rabab Debs; Caroline Espil-Taris; Laurent Kremer; Thierry Kuntzer; Pascal Laforêt; Vincent Laugel; Martial Mallaret; Maud Michaud; Sylvain Nollet; Juliette Svahn; Savine Vicart; Rocio Nur Villar-Quiles; Isabelle Desguerre; David Adams; Sandrine Segovia-Kueny; Géraldine Merret; Elhadi Hammouda; Annamaria Molon; Shahram Attarian
Source
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-9 (2021)
Subject
Language
English
ISSN
1750-1172
Abstract
Abstract Background Due to their health condition, patients with neuromuscular diseases (NMD) are at greater risk of developing serious complications with COVID-19. The objective of this study was to analyze the prevalence of COVID-19 among NMD patients and the risk factors for its impact and severity during the first wave of the pandemic. Clinical data were collected from NMD-COVID-19 patients, between March 25, 2020 and May 11, 2020 in an anonymous survey carried out by expert physicians from the French Health Care Network Filnemus. Results Physicians reported 84 patients, including: 34 with myasthenia gravis, 27 with myopathy and 23 with neuropathy. COVID-19 had no effect on NMD for 48 (58%) patients and 48 (58%) patients developed low COVID-19 severity. COVID-19 caused the death of 9 (11%) NMD patients. Diabetic patients were at greater risk of dying. Patients with diabetes, hypertension or severe forms of NMD had a higher risk of developing a moderate or severe form of COVID-19. In our cohort, corticosteroids and other immunosuppressants were not significantly associated with higher COVID-19 severity for acquired NMD. Conclusion During this period, a small percentage of French NMD patients was affected by COVID-19 compared to the general French population and COVID-19 had a limited short-term effect on them. Diabetes, hypertension and a severe degree of NMD were identified as risk factors of unfavorable outcome following COVID-19. Conversely, in our cohort of patients with acquired NMD, corticosteroids or other immunosuppressants did not appear to be risk factors for more severe COVID-19.