학술논문
A BAFF/APRIL axis regulates obesogenic diet-driven weight gain
Document Type
article
Author
Calvin C. Chan; Isaac T. W. Harley; Paul T. Pfluger; Aurelien Trompette; Traci E. Stankiewicz; Jessica L. Allen; Maria E. Moreno-Fernandez; Michelle S. M. A. Damen; Jarren R. Oates; Pablo C. Alarcon; Jessica R. Doll; Matthew J. Flick; Leah M. Flick; Joan Sanchez-Gurmaches; Rajib Mukherjee; Rebekah Karns; Michael Helmrath; Thomas H. Inge; Stuart P. Weisberg; Sünje J. Pamp; David A. Relman; Randy J. Seeley; Matthias H. Tschöp; Christopher L. Karp; Senad Divanovic
Source
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Interactions between the immune system and adipose tissue contribute to the regulation of body weight, however, the underlying mechanisms remain incompletely understood. Here the authors dissect the role of two structurally and functionally similar immune mediators, BAFF and APRIL, in modifying diet-induced weight gain and adipocyte lipid handling.