학술논문
CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer
Document Type
article
Author
Julia M. Houthuijzen; Roebi de Bruijn; Eline van der Burg; Anne Paulien Drenth; Ellen Wientjens; Tamara Filipovic; Esme Bullock; Chiara S. Brambillasca; Emilia M. Pulver; Marja Nieuwland; Iris de Rink; Frank van Diepen; Sjoerd Klarenbeek; Ron Kerkhoven; Valerie G. Brunton; Colinda L.G.J. Scheele; Mirjam C. Boelens; Jos Jonkers
Source
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
The origin of cancer-associated fibroblasts (CAFs) in cancer remains to be identified. Here, single-cell transcriptomics, in vivo and in vitro studies suggest that CD26+ and CD26- normal fibroblasts transform into distinct CAF subpopulations in mouse models of breast cancer.