학술논문
Single-Cell High-Throughput Technologies in Cerebrospinal Fluid Research and Diagnostics
Document Type
article
Source
Frontiers in Immunology, Vol 10 (2019)
Subject
Language
English
ISSN
1664-3224
Abstract
High-throughput single-cell technologies have recently emerged as essential tools in biomedical research with great potential for clinical pathology when studying liquid and solid biopsies. We provide an update on current single-cell methods in cerebrospinal fluid research and diagnostics, focusing on high-throughput cell-type specific proteomic and genomic technologies. Proteomic methods comprising flow cytometry and mass cytometry as well as genomic approaches including immune cell repertoire and single-cell transcriptomic studies are critically reviewed and future directions discussed.