학술논문
Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1
Document Type
article
Author
Julie Sellau; Marie Groneberg; Helena Fehling; Thorsten Thye; Stefan Hoenow; Claudia Marggraff; Marie Weskamm; Charlotte Hansen; Stephanie Stanelle-Bertram; Svenja Kuehl; Jill Noll; Vincent Wolf; Nahla Galal Metwally; Sven Hendrik Hagen; Christoph Dorn; Julia Wernecke; Harald Ittrich; Egbert Tannich; Thomas Jacobs; Iris Bruchhaus; Marcus Altfeld; Hannelore Lotter
Source
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Altered monocyte responses and testosterone levels correlate, individually, with the pathogenesis of hepatic amebiasis in mice. Here the authors show that testosterone induces enhanced TNF/CXCL1 expression and stronger proinflammatory responses in both human and mouse monocytes to support an androgen-monocyte axis of inflammation regulation.