부산대학교 도서관

Abstract Background Excessive respiratory muscle effort during mechanical ventilation may cause patient self-inflicted lung injury and load-induced diaphragm myotrauma, but there are no non-invasive methods to reliably detect elevated transpulmonary driving pressure and elevated respiratory muscle effort during assisted ventilation. We hypothesized that the swing in airway pressure generated by respiratory muscle effort under assisted ventilation when the airway is briefly occluded (ΔP occ) could be used as a highly feasible non-invasive technique to screen for these conditions. Methods Respiratory muscle pressure (P mus), dynamic transpulmonary driving pressure (ΔP L,dyn, the difference between peak and end-expiratory transpulmonary pressure), and ΔP occ were measured daily in mechanically ventilated patients in two ICUs in Toronto, Canada. A conversion factor to predict ΔP L,dyn and P mus from ΔP occ was derived and validated using cross-validation. External validity was assessed in an independent cohort (Nanjing, China). Results Fifty-two daily recordings were collected in 16 patients. In this sample, P mus and ΔP L were frequently excessively high: P mus exceeded 10 cm H2O on 84% of study days and ΔP L,dyn exceeded 15 cm H2O on 53% of study days. ΔP occ measurements accurately detected P mus > 10 cm H2O (AUROC 0.92, 95% CI 0.83–0.97) and ΔP L,dyn > 15 cm H2O (AUROC 0.93, 95% CI 0.86–0.99). In the external validation cohort (n = 12), estimating P mus and ΔP L,dyn from ΔP occ measurements detected excessively high P mus and ΔP L,dyn with similar accuracy (AUROC ≥ 0.94). Conclusions Measuring ΔP occ enables accurate non-invasive detection of elevated respiratory muscle pressure and transpulmonary driving pressure. Excessive respiratory effort and transpulmonary driving pressure may be frequent in spontaneously breathing ventilated patients.