부산대학교 도서관

Introduction. Physiological and endocrine changes occur during menopause that can negatively affect the sleep-wake cycle and contribute to objective and subjective sleep problems. Objective. To assess the effectiveness of a pharmaceutic intervention with two different complementary treatments and sleep hygiene education on climacteric symptoms and sleep domains in menopausal women with sleep disturbance. Material and methods. A sample of 109 women (45-64 years) participated in a 3-month randomized study, 35 received sleep hygiene instructions (SHI), 36 received capsules containing Passiflora incarnata 3 times a ay plus SHI (PI), and 38 received capsules containing Valerian officinalis 3 times a day plus SHI (VO). Participants were evaluated by a) the Menopause Quality of Life (MENQOL) instrument, b) Pittsburgh Sleep Quality Index (PSQI), c) Insomnia Severity Index, d) Epworth Sleepiness Scale, and e) Mental component of SF-12 health survey. Results. MENQOL scores were similar at baseline in the three groups but were reduced (improved vasomotor domain and physical subscale) at the end of the study in the VO group when compared with PI and SHI counterparts (both, p