학술논문
Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia
Document Type
article
Author
Quentin Van Thillo; Jolien De Bie; Janith A. Seneviratne; Sofie Demeyer; Sofia Omari; Anushree Balachandran; Vicki Zhai; Wai L. Tam; Bram Sweron; Ellen Geerdens; Olga Gielen; Sarah Provost; Heidi Segers; Nancy Boeckx; Glenn M. Marshall; Belamy B. Cheung; Kiyotaka Isobe; Itaru Kato; Junko Takita; Timothy G. Amos; Ira W. Deveson; Hannah McCalmont; Richard B. Lock; Ethan P. Oxley; Maximilian M. Garwood; Ross A. Dickins; Anne Uyttebroeck; Daniel R. Carter; Jan Cools; Charles E. de Bock
Source
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
SPI1 fusion genes in T-cell acute lymphoblastic leukemia (T-ALL) are commonly found with co-occurring NRAS mutations. Here, the authors show that the combination of these oncogenes is necessary to drive T-ALL in a murine model and that the oncogenic activity of the SPI1 fusion is dependent on β-catenin.