학술논문
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
Document Type
article
Author
Ioanna Ntalla; Lu-Chen Weng; James H. Cartwright; Amelia Weber Hall; Gardar Sveinbjornsson; Nathan R. Tucker; Seung Hoan Choi; Mark D. Chaffin; Carolina Roselli; Michael R. Barnes; Borbala Mifsud; Helen R. Warren; Caroline Hayward; Jonathan Marten; James J. Cranley; Maria Pina Concas; Paolo Gasparini; Thibaud Boutin; Ivana Kolcic; Ozren Polasek; Igor Rudan; Nathalia M. Araujo; Maria Fernanda Lima-Costa; Antonio Luiz P. Ribeiro; Renan P. Souza; Eduardo Tarazona-Santos; Vilmantas Giedraitis; Erik Ingelsson; Anubha Mahajan; Andrew P. Morris; Fabiola Del Greco M; Luisa Foco; Martin Gögele; Andrew A. Hicks; James P. Cook; Lars Lind; Cecilia M. Lindgren; Johan Sundström; Christopher P. Nelson; Muhammad B. Riaz; Nilesh J. Samani; Gianfranco Sinagra; Sheila Ulivi; Mika Kähönen; Pashupati P. Mishra; Nina Mononen; Kjell Nikus; Mark J. Caulfield; Anna Dominiczak; Sandosh Padmanabhan; May E. Montasser; Jeff R. O’Connell; Kathleen Ryan; Alan R. Shuldiner; Stefanie Aeschbacher; David Conen; Lorenz Risch; Sébastien Thériault; Nina Hutri-Kähönen; Terho Lehtimäki; Leo-Pekka Lyytikäinen; Olli T. Raitakari; Catriona L. K. Barnes; Harry Campbell; Peter K. Joshi; James F. Wilson; Aaron Isaacs; Jan A. Kors; Cornelia M. van Duijn; Paul L. Huang; Vilmundur Gudnason; Tamara B. Harris; Lenore J. Launer; Albert V. Smith; Erwin P. Bottinger; Ruth J. F. Loos; Girish N. Nadkarni; Michael H. Preuss; Adolfo Correa; Hao Mei; James Wilson; Thomas Meitinger; Martina Müller-Nurasyid; Annette Peters; Melanie Waldenberger; Massimo Mangino; Timothy D. Spector; Michiel Rienstra; Yordi J. van de Vegte; Pim van der Harst; Niek Verweij; Stefan Kääb; Katharina Schramm; Moritz F. Sinner; Konstantin Strauch; Michael J. Cutler; Diane Fatkin; Barry London; Morten Olesen; Dan M. Roden; M. Benjamin Shoemaker; J. Gustav Smith; Mary L. Biggs; Joshua C. Bis; Jennifer A. Brody; Bruce M. Psaty; Kenneth Rice; Nona Sotoodehnia; Alessandro De Grandi; Christian Fuchsberger; Cristian Pattaro; Peter P. Pramstaller; Ian Ford; J. Wouter Jukema; Peter W. Macfarlane; Stella Trompet; Marcus Dörr; Stephan B. Felix; Uwe Völker; Stefan Weiss; Aki S. Havulinna; Antti Jula; Katri Sääksjärvi; Veikko Salomaa; Xiuqing Guo; Susan R. Heckbert; Henry J. Lin; Jerome I. Rotter; Kent D. Taylor; Jie Yao; Renée de Mutsert; Arie C. Maan; Dennis O. Mook-Kanamori; Raymond Noordam; Francesco Cucca; Jun Ding; Edward G. Lakatta; Yong Qian; Kirill V. Tarasov; Daniel Levy; Honghuang Lin; Christopher H. Newton-Cheh; Kathryn L. Lunetta; Alison D. Murray; David J. Porteous; Blair H. Smith; Bruno H. Stricker; André Uitterlinden; Marten E. van den Berg; Jeffrey Haessler; Rebecca D. Jackson; Charles Kooperberg; Ulrike Peters; Alexander P. Reiner; Eric A. Whitsel; Alvaro Alonso; Dan E. Arking; Eric Boerwinkle; Georg B. Ehret; Elsayed Z. Soliman; Christy L. Avery; Stephanie M. Gogarten; Kathleen F. Kerr; Cathy C. Laurie; Amanda A. Seyerle; Adrienne Stilp; Solmaz Assa; M. Abdullah Said; M. Yldau van der Ende; Pier D. Lambiase; Michele Orini; Julia Ramirez; Stefan Van Duijvenboden; David O. Arnar; Daniel F. Gudbjartsson; Hilma Holm; Patrick Sulem; Gudmar Thorleifsson; Rosa B. Thorolfsdottir; Unnur Thorsteinsdottir; Emelia J. Benjamin; Andrew Tinker; Kari Stefansson; Patrick T. Ellinor; Yalda Jamshidi; Steven A. Lubitz; Patricia B. Munroe
Source
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
On the electrocardiogram, the PR interval reflects conduction from the atria to ventricles and also serves as risk indicator of cardiovascular morbidity and mortality. Here, the authors perform genome-wide meta-analyses for PR interval in multiple ancestries and identify 141 previously unreported genetic loci.