학술논문
Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma
Document Type
article
Author
Alexandra Gyurdieva; Stefan Zajic; Ya-Fang Chang; E. Andres Houseman; Shan Zhong; Jaegil Kim; Michael Nathenson; Thomas Faitg; Mary Woessner; David C. Turner; Aisha N. Hasan; John Glod; Rosandra N. Kaplan; Sandra P. D’Angelo; Dejka M. Araujo; Warren A. Chow; Mihaela Druta; George D. Demetri; Brian A. Van Tine; Stephan A. Grupp; Gregg D. Fine; Ioanna Eleftheriadou
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Biomarkers predictive of response to T cell therapy remain to be better defined. This study identifies potential predictive and pharmacodynamic markers of response to NY-ESO-1 T-cell therapy in a solid tumor that may inform lymphodepletion, cell dose, and strategies to enhance anticancer efficacy.