학술논문
An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortium
Document Type
article
Author
Margitta Worm; Aikaterina Alexiou; Veronika Höfer; Till Birkner; Alexander C. S. N. Jeanrenaud; Florent Fauchère; Kristijan Pazur; Carolin Steinert; Aleix Arnau‐Soler; Priyanka Banerjee; Andreas Diefenbach; Josefine Dobbertin‐Welsch; Sabine Dölle‐Bierke; Wojciech Francuzik; Ahla Ghauri; Stephanie Heller; Birgit Kalb; Ulrike Löber; Ingo Marenholz; Lajos Markó; Jörg Scheffel; Olena Potapenko; Stephanie Roll; Susanne Lau; Young‐Ae Lee; Julian Braun; Andreas Thiel; Magda Babina; Sabine Altrichter; Sofia Kirke Forslund; Kirsten Beyer
Source
Clinical and Translational Allergy, Vol 12, Iss 10, Pp n/a-n/a (2022)
Subject
Language
English
ISSN
2045-7022
Abstract
Background Peanut allergy is a frequent cause of food allergy and potentially life‐threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus non‐allergic controls. Methods Biosamples were studied regarding DNA methylation signatures, gut microbiome, adaptive and innate immune cell populations, soluble signaling molecules and allergen‐reactive antibody specificities. We applied a scalable systems medicine computational workflow to the assembled data. Results We identified combined cellular and soluble biomarker signatures that stratify donors into peanut‐allergic and non‐allergic with high specificity. DNA methylation profiling revealed various genes of interest and stool microbiota differences in bacteria abundances. Conclusion By extending our findings to a larger set of patients (e.g., children vs. adults), we will establish predictors for food allergy and tolerance and translate these as for example, indicators for interventional studies.