학술논문
Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions
Document Type
article
Author
Source
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Innate T cells (ITC) contain many subsets and are poised to promptly respond to antigens and pathogens, but how this poised state is maintained is still unclear. Here the authors perform single-cell RNA-seq to align the various ITC subsets along an ‘innateness gradient’ that is associated with changes in proliferation and effector functions.