학술논문
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence
Document Type
article
Author
Kwinten Sliepen; Byung Woo Han; Ilja Bontjer; Petra Mooij; Fernando Garces; Anna-Janina Behrens; Kimmo Rantalainen; Sonu Kumar; Anita Sarkar; Philip J. M. Brouwer; Yuanzi Hua; Monica Tolazzi; Edith Schermer; Jonathan L. Torres; Gabriel Ozorowski; Patricia van der Woude; Alba Torrents de la Peña; Mariëlle J. van Breemen; Juan Miguel Camacho-Sánchez; Judith A. Burger; Max Medina-Ramírez; Nuria González; Jose Alcami; Celia LaBranche; Gabriella Scarlatti; Marit J. van Gils; Max Crispin; David C. Montefiori; Andrew B. Ward; Gerrit Koopman; John P. Moore; Robin J. Shattock; Willy M. Bogers; Ian A. Wilson; Rogier W. Sanders
Source
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Stabilized, native-like trimers of the HIV envelope protein, such as SOSIP trimers, are potential antigens for an HIV vaccine. Here, the authors generate a SOSIP trimer based on the consensus sequence of group M isolates, determine its structure and exposure of common epitopes, and show immunogenicity in rabbits and non-human primates.