학술논문
Spatially resolved tissue imaging to analyze the tumor immune microenvironment: beyond cell-type densities
Document Type
article
Author
Source
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)
Subject
Language
English
ISSN
2051-1426
Abstract
Introduction The tissue immune microenvironment is associated with key aspects of tumor biology. The interaction between the immune system and cancer cells has predictive and prognostic potential across different tumor types. Spatially resolved tissue-based technologies allowed researchers to simultaneously quantify different immune populations in tumor samples. However, bare quantification fails to harness the spatial nature of tissue-based technologies. Tumor-immune interactions are associated with specific spatial patterns that can be measured. In recent years, several computational tools have been developed to increase our understanding of these spatial patterns.Topics covered In this review, we cover standard techniques as well as new advances in the field of spatial analysis of the immune microenvironment. We focused on marker quantification, spatial intratumor heterogeneity analysis, cell‒cell spatial interaction studies and neighborhood analyses.