학술논문
FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells
Document Type
article
Author
Source
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Subject
Language
English
ISSN
2399-3642
Abstract
A synthetic lethal interaction is reported between the R-loop helicase Senataxin (SETX) and Fanconi anemia pathway proteins, with SETX deficiency increasing replication stress-induced chromosome fragility & activation of mitotic DNA synthesis.