학술논문
Blood DNA methylation signatures are associated with social determinants of health among survivors of childhood cancer
Document Type
article
Author
Nan Song; Jin-Ah Sim; Qian Dong; Yinan Zheng; Lifang Hou; Zhenghong Li; Chia-Wei Hsu; Haitao Pan; Heather Mulder; John Easton; Emily Walker; Geoffrey Neale; Carmen L. Wilson; Kirsten K. Ness; Kevin R. Krull; Deo Kumar Srivastava; Yutaka Yasui; Jinghui Zhang; Melissa M. Hudson; Leslie L. Robison; I-Chan Huang; Zhaoming Wang
Source
Epigenetics, Vol 17, Iss 11, Pp 1389-1403 (2022)
Subject
Language
English
ISSN
1559-2294
1559-2308
15592294
1559-2308
15592294
Abstract
Social epigenomics is an emerging field in which social scientist collaborate with computational biologists, especially epigeneticists, to address the underlying pathway for biological embedding of life experiences. This social epigenomics study included long-term childhood cancer survivors enrolled in the St. Jude Lifetime Cohort. DNA methylation (DNAm) data were generated using the Illumina EPIC BeadChip, and three social determinants of health (SDOH) factors were assessed: self-reported educational attainment, personal income, and an area deprivation index based on census track data. An epigenome-wide association study (EWAS) was performed to evaluate the relation between DNAm at each 5’-cytosine-phosphate-guanine-3’ (CpG) site and each SDOH factor based on multivariable linear regression models stratified by ancestry (European ancestry, n = 1,618; African ancestry, n = 258). EWAS among survivors of European ancestry identified 130 epigenome-wide significant SDOH–CpG associations (P