학술논문
SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself
Document Type
article
Author
Marta Ferreira-Gomes; Andrey Kruglov; Pawel Durek; Frederik Heinrich; Caroline Tizian; Gitta Anne Heinz; Anna Pascual-Reguant; Weijie Du; Ronja Mothes; Chaofan Fan; Stefan Frischbutter; Katharina Habenicht; Lisa Budzinski; Justus Ninnemann; Peter K. Jani; Gabriela Maria Guerra; Katrin Lehmann; Mareen Matz; Lennard Ostendorf; Lukas Heiberger; Hyun-Dong Chang; Sandy Bauherr; Marcus Maurer; Günther Schönrich; Martin Raftery; Tilmann Kallinich; Marcus Alexander Mall; Stefan Angermair; Sascha Treskatsch; Thomas Dörner; Victor Max Corman; Andreas Diefenbach; Hans-Dieter Volk; Sefer Elezkurtaj; Thomas H. Winkler; Jun Dong; Anja Erika Hauser; Helena Radbruch; Mario Witkowski; Fritz Melchers; Andreas Radbruch; Mir-Farzin Mashreghi
Source
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Our understanding on the humoral immunity induced by SARS-CoV-2 is still lacking. Here the authors analyze B cell responses at the single cell level to find that, in severe COVID-19 patients, plasmablasts shift from IFN to TGFβ instruction to produce IgA antibodies that are not specific to dominant SARS-CoV-2 antigens.