학술논문
DNA methylation and gene expression analysis in adipose tissue to identify new loci associated with T2D development in obesity
Document Type
article
Author
Source
Nutrition & Diabetes, Vol 12, Iss 1, Pp 1-7 (2022)
Subject
Language
English
ISSN
2044-4052
Abstract
Abstract Background Obesity is accompanied by excess adipose fat storage, which may lead to adipose dysfunction, insulin resistance, and type 2 diabetes (T2D). Currently, the tendency to develop T2D in obesity cannot be explained by genetic variation alone—epigenetic mechanisms, such as DNA methylation, might be involved. Here, we aimed to identify changes in DNA methylation and gene expression in visceral adipose tissue (VAT) that might underlie T2D susceptibility in patients with obesity. Methods We investigated DNA methylation and gene expression in VAT biopsies from 19 women with obesity, without (OND = 9) or with T2D (OD = 10). Differences in genome-scale methylation (differentially methylated CpGs [DMCs], false discovery rate