학술논문
Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis
Document Type
article
Author
Mengfei Liu; Sheng Cao; Li He; Jinhang Gao; Juan P. Arab; Huarui Cui; Weixia Xuan; Yandong Gao; Tejasav S. Sehrawat; Feda H. Hamdan; Meritxell Ventura-Cots; Josepmaria Argemi; William C. K. Pomerantz; Steven A. Johnsen; Jeong-Heon Lee; Fei Gao; Tamas Ordog; Philippe Mathurin; Alexander Revzin; Ramon Bataller; Huihuang Yan; Vijay H. Shah
Source
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Alcoholic hepatitis is characterized by intense liver inflammation driven by excessive cytokines and chemokines production and immune cell infiltration. Here the authors identify a super-enhancer that regulates the expression of multiple CXCL chemokines in alcoholic hepatitis and may be a potential therapeutic target.