학술논문

Sinapic acid modulates oxidative stress and metabolic disturbances to attenuate ovarian fibrosis in letrozole‐induced polycystic ovary syndrome SD rats
Document Type
article
Source
Food Science & Nutrition, Vol 12, Iss 4, Pp 2917-2931 (2024)
Subject
fibrosis
metabolic disturbances
oxidative stress
polycystic ovary syndrome
sinapic acid
TGF‐β1/Smads
Nutrition. Foods and food supply
TX341-641
Language
English
ISSN
2048-7177
Abstract
Abstract Sinapic acid (SA) is renowned for its many pharmacological activities as a polyphenolic compound. The cause of polycystic ovary syndrome (PCOS), a commonly encountered array of metabolic and hormonal abnormalities in females, has yet to be determined. The present experiment was performed to evaluate the antifibrotic properties of SA in rats with letrozole‐induced PCOS‐related ovarian fibrosis. SA treatment successfully mitigated the changes induced by letrozole in body weight (BW) (p