학술논문
Enantioselective [3 + 2] cycloadditions of terminal allenoates with β-sulfonyl-α,β-unsaturated ketones
Document Type
article
Author
Source
Green Synthesis and Catalysis, Vol 4, Iss 1, Pp 54-57 (2023)
Subject
Language
English
ISSN
2666-5549
Abstract
A highly efficient and mild method for [3 + 2] cycloaddition of β-sulfonyl-α,β-unsaturated ketones with terminal allenoates was well-explored and developed. The reactions were successfully performed by applying multifunctional chiral phosphine P6 which was screened from eight chiral phosphorus reagents to finally result in a variety of enantioenriched sulfone-substituted cyclopentenes with two chiral centers (up to 81% yield with 94% ee). Moreover, 2.5 mol% catalytic equivalents were proved to be feasible when this reaction was performed on a 10 mmol scale.