학술논문
Non-linear patterns in age-related DNA methylation may reflect CD4+ T cell differentiation
Document Type
article
Author
Source
Epigenetics, Vol 12, Iss 6, Pp 492-503 (2017)
Subject
Language
English
ISSN
1559-2294
1559-2308
15592294
1559-2308
15592294
Abstract
DNA methylation (DNAm) is an important epigenetic process involved in the regulation of gene expression. While many studies have identified thousands of loci associated with age, few have differentiated between linear and non-linear DNAm trends with age. Non-linear trends could indicate early- or late-life gene regulatory processes. Using data from the Illumina 450K array on 336 human peripheral blood samples, we identified 21 CpG sites that associated with age (P