학술논문
AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumourigenesis
Document Type
article
Author
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Energy stress activates AMPK leading to metabolic plasticity and therapy resistance in cancer. Here, the authors show that AMPK activation decreases Prospero-related homeobox 1 (PROX1) levels impairing branched amino acid metabolism and tumourigenesis in liver and lung cancer models.