학술논문
The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi
Document Type
article
Author
Louisa L. Y. Chan; Danielle E. Anderson; Hong Sheng Cheng; Fransiskus Xaverius Ivan; Si Chen; Adrian E. Z. Kang; Randy Foo; Akshamal M. Gamage; Pei Yee Tiew; Mariko Siyue Koh; Ken Cheah Hooi Lee; Kristy Nichol; Prabuddha S. Pathinayake; Yik Lung Chan; Tsin Wen Yeo; Brian G. Oliver; Peter A. B. Wark; Linbo Liu; Nguan Soon Tan; Lin-Fa Wang; Sanjay H. Chotirmall
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory respiratory disease characterized by airflow limitation and infective exacerbations. Here, Chan et al. report the generation of nasopharyngeal and bronchial COPD organoids derived from adult stem cells and employ them in the study of host-pathogen interactions, including SARS-CoV-2 and Pseudomonas aeruginosa.