학술논문

Recurrent sideroblastic anemia during pregnancy
Document Type
article
Source
Clinical Case Reports, Vol 11, Iss 1, Pp n/a-n/a (2023)
Subject
acquired sideroblastic anemia
congenital sideroblastic anemia
heme biosynthesis
iron chelation
ring sideroblasts
vitamin B6
Medicine
Medicine (General)
R5-920
Language
English
ISSN
2050-0904
Abstract
Abstract Sideroblastic anemia is a heterogeneous group of disorders typified by the presence of ring sideroblasts in the bone marrow and has congenital and acquired types. Sideroblastic anemia is a rare event in pregnancy. We report a case of a 32‐year‐old female patient, gravida 4 para 3, 27th weeks pregnant, who presented to the emergency department complaining of palpitation and generalized weakness for 2 weeks. She was found to have severe normochromic normocytic anemia, with hemoglobin of 4.2 g/dl, and low reticulocytes count of 13 × 103/μl. She gave a history of recurrent anemia, which had only occurred during pregnancy. Her bone marrow aspirate showed many ring sideroblasts concluding the diagnosis of sideroblastic anemia (SA). Further investigation revealed a significantly low pyridoxine level (vitamin B6) of (8 nmol/L). The Hb level improved with vitamin B6 replacement, without any transfusion support.