학술논문
Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer
Document Type
article
Author
David Liu; Philip Abbosh; Daniel Keliher; Brendan Reardon; Diana Miao; Kent Mouw; Amaro Weiner-Taylor; Stephanie Wankowicz; Garam Han; Min Yuen Teo; Catharine Cipolla; Jaegil Kim; Gopa Iyer; Hikmat Al-Ahmadie; Essel Dulaimi; David Y. T. Chen; R. Katherine Alpaugh; Jean Hoffman-Censits; Levi A. Garraway; Gad Getz; Scott L. Carter; Joaquim Bellmunt; Elizabeth R. Plimack; Jonathan E. Rosenberg; Eliezer M. Van Allen
Source
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
The impact of cisplatin-based chemotherapy on tumor genomes is complex. Here, the authors study matched pre- and post-chemotherapy primary samples in muscle-invasive bladder cancer, finding a cisplatin-based mutational signature, and highlighting the impact of intratumor heterogeneity on survival.