학술논문
A Novel Framework for Phenotyping Children With Suspected or Confirmed Infection for Future Biomarker Studies
Document Type
article
Author
Ruud G. Nijman; Rianne Oostenbrink; Henriette A. Moll; Climent Casals-Pascual; Ulrich von Both; Aubrey Cunnington; Tisham De; Irini Eleftheriou; Marieke Emonts; Colin Fink; Michiel van der Flier; Ronald de Groot; Myrsini Kaforou; Benno Kohlmaier; Taco W. Kuijpers; Emma Lim; Ian K. Maconochie; Stephane Paulus; Federico Martinon-Torres; Marko Pokorn; Sam T. Romaine; Irene Rivero Calle; Luregn J. Schlapbach; Frank J. Smit; Maria Tsolia; Effua Usuf; Victoria J. Wright; Shunmay Yeung; Dace Zavadska; Werner Zenz; Michael Levin; Jethro A. Herberg; Enitan D. Carrol; The PERFORM consortium (Personalized Risk assessment in febrile children to optimize Real-life Management across the European Union)
Source
Frontiers in Pediatrics, Vol 9 (2021)
Subject
Language
English
ISSN
2296-2360
Abstract
Background: The limited diagnostic accuracy of biomarkers in children at risk of a serious bacterial infection (SBI) might be due to the imperfect reference standard of SBI. We aimed to evaluate the diagnostic performance of a new classification algorithm for biomarker discovery in children at risk of SBI.Methods: We used data from five previously published, prospective observational biomarker discovery studies, which included patients aged 0–