학술논문
miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia
Document Type
article
Author
Xi Jiang; Chao Hu; Stephen Arnovitz; Jason Bugno; Miao Yu; Zhixiang Zuo; Ping Chen; Hao Huang; Bryan Ulrich; Sandeep Gurbuxani; Hengyou Weng; Jennifer Strong; Yungui Wang; Yuanyuan Li; Justin Salat; Shenglai Li; Abdel G. Elkahloun; Yang Yang; Mary Beth Neilly; Richard A. Larson; Michelle M. Le Beau; Tobias Herold; Stefan K. Bohlander; Paul P. Liu; Jiwang Zhang; Zejuan Li; Chuan He; Jie Jin; Seungpyo Hong; Jianjun Chen
Source
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Mir-22 has been shown to be an oncogenic microRNA in breast cancer and myelodysplastic syndrome. Here, the authors show that mir-22 functions as a tumour suppressor in de novoacute myeloid leukaemia by inhibiting the expression of several oncogenes and that restoring mir-22 expression suppresses AML progression.