학술논문
Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe
Document Type
article
Author
Kimberley S.M. Benschop; Eeva K. Broberg; Emma Hodcroft; Dennis Schmitz; Jan Albert; Anda Baicus; Jean-Luc Bailly; Gudrun Baldvinsdottir; Natasa Berginc; Soile Blomqvist; Sindy Böttcher; Mia Brytting; Erika Bujaki; Maria Cabrerizo; Cristina Celma; Ondrej Cinek; Eric C.J. Claas; Jeroen Cremer; Jonathan Dean; Jennifer L. Dembinski; Iryna Demchyshyna; Sabine Diedrich; Susanne Dudman; Jake Dunning; Robert Dyrdak; Mary Emmanouil; Agnes Farkas; Cillian De Gascun; Guillaume Fournier; Irina Georgieva; Ruben Gonzalez-Sanz; Jolanda van Hooydonk-Elving; Anne J. Jääskeläinen; Ruta Jancauskaite; Kathrin Keeren; Thea K. Fischer; Sidsel Krokstad; Lubomira Nikolaeva–Glomb; Ludmila Novakova; Sofie E. Midgley; Audrey Mirand; Richard Molenkamp; Ursula Morley; Joël Mossong; Svajune Muralyte; Jean-Luc Murk; Trung Nguyen; Svein A. Nordbø; Riikka Österback; Suzan Pas; Laura Pellegrinelli; Vassiliki Pogka; Birgit Prochazka; Petra Rainetova; Marc Van Ranst; Lieuwe Roorda; Isabelle Schuffenecker; Rob Schuurman; Asya Stoyanova; Kate Templeton; Jaco J. Verweij; Androniki Voulgari-Kokota; Tytti Vuorinen; Elke Wollants; Katja C. Wolthers; Katherina Zakikhany; Richard Neher; Heli Harvala; Peter Simmonds
Source
Emerging Infectious Diseases, Vol 27, Iss 6, Pp 1616-1626 (2021)
Subject
Language
English
ISSN
1080-6040
1080-6059
1080-6059
Abstract
In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016–2018. Most E30 cases affected persons 0–4 years of age (29%) and 25–34 years of age (27%). Sequences were divided into 6 genetic clades (G1–G6). Most (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), and G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 and G4 displayed >2 unique recombinant forms. Rapid turnover of new clades and recombinant forms occurred over time. Clades G1 and G6 dominated in 2018, suggesting the E30 upsurge was caused by emergence of 2 distinct clades circulating in Europe. Investigation into the mechanisms behind the rapid turnover of E30 is crucial for clarifying the epidemiology and evolution of these enterovirus infections.