학술논문
Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours
Document Type
article
Author
Peter A. Johansson; Kelly Brooks; Felicity Newell; Jane M. Palmer; James S. Wilmott; Antonia L. Pritchard; Natasa Broit; Scott Wood; Matteo S. Carlino; Conrad Leonard; Lambros T. Koufariotis; Vaishnavi Nathan; Aaron B. Beasley; Madeleine Howlie; Rebecca Dawson; Helen Rizos; Chris W. Schmidt; Georgina V. Long; Hayley Hamilton; Jens F. Kiilgaard; Timothy Isaacs; Elin S. Gray; Olivia J. Rolfe; John J. Park; Andrew Stark; Graham J. Mann; Richard A. Scolyer; John V. Pearson; Nicolas van Baren; Nicola Waddell; Karin W. Wadt; Lindsay A. McGrath; Sunil K. Warrier; William Glasson; Nicholas K. Hayward
Source
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Uveal melanoma has a propensity to metastasise. Here, the authors report the whole genome sequence of 103 uveal melanomas and find that the tumour mutational burden is variable and that two subsets of tumours are characterised by MBD4 mutations and a UV exposure signature.