학술논문
Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy
Document Type
article
Author
Marcel P. Trefny; Nicole Kirchhammer; Priska Auf der Maur; Marina Natoli; Dominic Schmid; Markus Germann; Laura Fernandez Rodriguez; Petra Herzig; Jonas Lötscher; Maryam Akrami; Jane C. Stinchcombe; Michal A. Stanczak; Andreas Zingg; Melanie Buchi; Julien Roux; Romina Marone; Leyla Don; Didier Lardinois; Mark Wiese; Lukas T. Jeker; Mohamed Bentires-Alj; Jérémie Rossy; Daniela S. Thommen; Gillian M. Griffiths; Heinz Läubli; Christoph Hess; Alfred Zippelius
Source
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
The efficacy of T-cell-based cancer immunotherapies can be compromised by T cell exhaustion. Here the authors develop a human ex vivo exhaustion model and, based on a CRISPR-Cas9 screen, identify SNX9 as a regulator of T cell exhaustion, showing that SNX9 knockout is associated with improved T cell function and anti-tumor activity in preclinical cancer models.