학술논문
Nodal immune flare mimics nodal disease progression following neoadjuvant immune checkpoint inhibitors in non-small cell lung cancer
Document Type
article
Author
Tina Cascone; Annikka Weissferdt; Myrna C. B. Godoy; William N. William; Cheuk H. Leung; Heather Y. Lin; Sreyashi Basu; Shalini S. Yadav; Apar Pataer; Kyle G. Mitchell; Md Abdul Wadud Khan; Yushu Shi; Cara Haymaker; Luisa M. Solis; Edwin R. Parra; Humam Kadara; Ignacio I. Wistuba; Padmanee Sharma; James P. Allison; Nadim J. Ajami; Jennifer A. Wargo; Robert R. Jenq; Don L. Gibbons; J. Jack Lee; Stephen G. Swisher; Ara A. Vaporciyan; John V. Heymach; Boris Sepesi
Source
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Granulomatous/sarcoid-like lesions have been reported in patients treated with immune checkpoint inhibitors (ICIs). Here the authors report the occurrence of “nodal immune flare”, an apparent radiological cancer progression in the nodes characterized by the absence of cancer and the presence of non-caseating granulomas, in patients with non-small cell lung cancer following neoadjuvant ICI treatment.