학술논문
Mitochondrial DNA copy number is associated with breast cancer risk.
Document Type
article
Author
Source
PLoS ONE, Vol 8, Iss 6, p e65968 (2013)
Subject
Language
English
ISSN
1932-6203
Abstract
Mitochondrial DNA (mtDNA) copy number in peripheral blood is associated with increased risk of several cancers. However, data from prospective studies on mtDNA copy number and breast cancer risk are lacking. We evaluated the association between mtDNA copy number in peripheral blood and breast cancer risk in a nested case-control study of 183 breast cancer cases with pre-diagnostic blood samples and 529 individually matched controls among participants of the Singapore Chinese Health Study. The mtDNA copy number was measured using real time PCR. Conditional logistic regression analyses showed that there was an overall positive association between mtDNA copy number and breast cancer risk (P(trend) = 0.01). The elevated risk for higher mtDNA copy numbers was primarily seen for women with