학술논문
Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci
Document Type
article
Author
Xianyong Yin; Lap Sum Chan; Debraj Bose; Anne U. Jackson; Peter VandeHaar; Adam E. Locke; Christian Fuchsberger; Heather M. Stringham; Ryan Welch; Ketian Yu; Lilian Fernandes Silva; Susan K. Service; Daiwei Zhang; Emily C. Hector; Erica Young; Liron Ganel; Indraniel Das; Haley Abel; Michael R. Erdos; Lori L. Bonnycastle; Johanna Kuusisto; Nathan O. Stitziel; Ira M. Hall; Gregory R. Wagner; FinnGen; Jian Kang; Jean Morrison; Charles F. Burant; Francis S. Collins; Samuli Ripatti; Aarno Palotie; Nelson B. Freimer; Karen L. Mohlke; Laura J. Scott; Xiaoquan Wen; Eric B. Fauman; Markku Laakso; Michael Boehnke
Source
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
The Finnish population is enriched for genetic variants which are rare in other populations. Here, the authors find new genetic loci associated with 1391 circulating metabolites in 6136 Finnish men, demonstrating that metabolite genetic associations can help elucidate disease mechanisms.