학술논문
Symptomatic, clinical and biomarker associations for mortality in hospitalized COVID-19 patients enriched for African Americans
Document Type
article
Author
Hassan Ashktorab; Antonio Pizuorno; Folake Adeleye; Adeyinka Laiyemo; Maryam Mehdipour Dalivand; Farshad Aduli; Zaki A. Sherif; Gholamreza Oskrochi; Kibreab Angesom; Philip Oppong-Twene; Suryanarayana Reddy Challa; Nnaemeka Okorie; Esther S. Moon; Edward Romos; Boubini Jones-Wonni; Abdoul Madjid Kone; Sheldon Rankine; Camelita Thrift; Derek Scholes; Chiamaka Ekwunazu; Abigail Banson; Brianna Mitchell; Guttu Maskalo; Jillian Ross; Julencia Curtis; Rachel Kim; Chandler Gilliard; Geetha Ahuja; Joseph Mathew; Warren Gavin; Areeba Kara; Manuel Hache-Marliere; Leonidas Palaiodimos; Vishnu R. Mani; Aleksandr Kalabin; Vijay Reddy Gayam; Pavani Reddy Garlapati; Joseph Miller; Lakshmi Gayathri Chirumamilla; Fatimah Jackson; John M. Carethers; Farin Kamangar; Hassan Brim
Source
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-13 (2022)
Subject
Language
English
ISSN
1471-2334
Abstract
Abstract Background and Aims Initial reports on US COVID-19 showed different outcomes in different races. In this study we use a diverse large cohort of hospitalized COVID-19 patients to determine predictors of mortality. Methods We analyzed data from hospitalized COVID-19 patients (n = 5852) between March 2020- August 2020 from 8 hospitals across the US. Demographics, comorbidities, symptoms and laboratory data were collected. Results The cohort contained 3,662 (61.7%) African Americans (AA), 286 (5%) American Latinx (LAT), 1,407 (23.9%), European Americans (EA), and 93 (1.5%) American Asians (AS). Survivors and non-survivors mean ages in years were 58 and 68 for AA, 58 and 77 for EA, 44 and 61 for LAT, and 51 and 63 for AS. Mortality rates for AA, LAT, EA and AS were 14.8, 7.3, 16.3 and 2.2%. Mortality increased among patients with the following characteristics: age, male gender, New York region, cardiac disease, COPD, diabetes mellitus, hypertension, history of cancer, immunosuppression, elevated lymphocytes, CRP, ferritin, D-Dimer, creatinine, troponin, and procalcitonin. Use of mechanical ventilation (p = 0.001), shortness of breath (SOB) (p