학술논문
PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma
Document Type
article
Author
Virginia Giuliani; Meredith A. Miller; Chiu-Yi Liu; Stella R. Hartono; Caleb A. Class; Christopher A. Bristow; Erika Suzuki; Lionel A. Sanz; Guang Gao; Jason P. Gay; Ningping Feng; Johnathon L. Rose; Hideo Tomihara; Joseph R. Daniele; Michael D. Peoples; Jennifer P. Bardenhagen; Mary K. Geck Do; Qing E. Chang; Bhavatarini Vangamudi; Christopher Vellano; Haoqiang Ying; Angela K. Deem; Kim-Anh Do; Giannicola Genovese; Joseph R. Marszalek; Jeffrey J. Kovacs; Michael Kim; Jason B. Fleming; Ernesto Guccione; Andrea Viale; Anirban Maitra; M. Emilia Di Francesco; Timothy A. Yap; Philip Jones; Giulio Draetta; Alessandro Carugo; Frederic Chedin; Timothy P. Heffernan
Source
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Arginine methylation by PRMTs is dysregulated in cancer. Here, the authors use functional genomics screens and identify PRMT1 as a vulnerability in pancreatic ductal adenocarcinoma, and further show that PRMT1 regulates RNA metabolism and coordinates expression of genes in cell cycle progression, maintaining genomic stability and tumour growth.