학술논문
Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children, Southwest Germany, May–August 2020
Document Type
article
Author
Maximilian Stich; Roland Elling; Hanna Renk; Aleš Janda; Sven F. Garbade; Barbara Müller; Hans-Georg Kräusslich; Dorit Fabricius; Maria Zernickel; Peter Meissner; Daniela Huzly; Jürgen Grulich-Henn; Anneke Haddad; Tessa Görne; Benedikt Spielberger; Linus Fritsch; Alexandra Nieters; Hartmut Hengel; Andrea N. Dietz; Thomas Stamminger; Tina Ganzenmueller; Natalia Ruetalo; Andreas Peter; Jonathan Remppis; Thomas Iftner; Kathrin Jeltsch; Tim Waterboer; Axel R. Franz; Georg Friedrich Hoffmann; Corinna Engel; Klaus-Michael Debatin; Burkhard Tönshoff; Philipp Henneke
Source
Emerging Infectious Diseases, Vol 27, Iss 12, Pp 3009-3019 (2021)
Subject
Language
English
ISSN
1080-6040
1080-6059
1080-6059
Abstract
Resolving the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in households with members from different generations is crucial for containing the current pandemic. We conducted a large-scale, multicenter, cross-sectional seroepidemiologic household transmission study in southwest Germany during May 11–August 1, 2020. We included 1,625 study participants from 405 households that each had ≥1 child and 1 reverse transcription PCR–confirmed SARS-CoV-2–infected index case-patient. The overall secondary attack rate was 31.6% and was significantly higher in exposed adults (37.5%) than in children (24.6%–29.2%; p = 60 years of age (72.9%; p = 0.039). Other risk factors for infectiousness of the index case-patient were SARS-CoV-2–seropositivity (odds ratio [OR] 27.8, 95% CI 8.26–93.5), fever (OR 1.93, 95% CI 1.14–3.31), and cough (OR 2.07, 95% CI 1.21–3.53). Secondary infections in household contacts generate a substantial disease burden.