학술논문
High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection
Document Type
article
Author
Eva-Maria Jacobsen; Dorit Fabricius; Magdalena Class; Fernando Topfstedt; Raquel Lorenzetti; Iga Janowska; Franziska Schmidt; Julian Staniek; Maria Zernickel; Thomas Stamminger; Andrea N. Dietz; Angela Zellmer; Manuel Hecht; Peter Rauch; Carmen Blum; Carolin Ludwig; Bernd Jahrsdörfer; Hubert Schrezenmeier; Maximilian Heeg; Benjamin Mayer; Alina Seidel; Rüdiger Groß; Jan Münch; Frank Kirchhoff; Sebastian F. N. Bode; Gudrun Strauss; Hanna Renk; Roland Elling; Maximillian Stich; Reinhard E. Voll; Burkhard Tönshof; Axel R. Franz; Philipp Henneke; Klaus-Michael Debatin; Marta Rizzi; Ales Janda
Source
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Severity of SARS-CoV-2 infection is different in adults and children which involves the immune response. Here using a parent and children cohort with 4 month and 12 month sampling times, the authors show enhanced levels and increased breadth of anti-spike antibody level over time but reduced specific T cell and B cell numbers in children.