부산대학교 도서관

Haoran Chen,1,2,* Zhongyu Han,2,* Yi Wang,1,* Junyan Su,3 Yumeng Lin,4 Xuhua Cheng,1 Wen Liu,1 Jingyu He,5 Yiyue Fan,6 Liuyan Chen,2 Houdong Zuo1 1Department of Orthopaedics, Chengdu Xinhua Hospital, Chengdu, 610000, People’s Republic of China; 2School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, 610000, People’s Republic of China; 3Department of Orthopaedics, The First People’s Hospital of Longquanyi District, Chengdu, 610000, People’s Republic of China; 4School of Ophthalmology, Chengdu University of Traditional Chinese Medicine, Chengdu, 610000, People’s Republic of China; 5Sichuan Judicial and Police Officers Professional College, Deyang, 618000, People’s Republic of China; 6Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Houdong Zuo, Department of Orthopaedics, Chengdu Xinhua Hospital, Chengdu, 610000, People’s Republic of China, Email xhyyzhd@163.com Liuyan Chen, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, 610000, People’s Republic of China, Email Lycheecly@163.comAbstract: Ferroptosis is a new cell fate decision discovered in recent years. Unlike apoptosis, autophagy or pyroptosis, ferroptosis is characterized by iron-dependent lipid peroxidation and mitochondrial morphological changes. Ferroptosis is involved in a variety of physiological and pathological processes. Since its discovery, ferroptosis has been increasingly studied concerning bone-related diseases. In this review, we focus on the latest research progress and prospects, summarize the regulatory mechanisms of ferroptosis, and discuss the role of ferroptosis in the pathogenesis of bone-related diseases, such as osteoporosis (OP), osteoarthritis (OA), rheumatoid arthritis (RA), and osteosarcoma (OS), as well as its therapeutic potential.Keywords: ferroptosis, cell death, iron accumulation, lipid peroxidation, bone-related diseases