학술논문
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints
Document Type
article
Author
Yi Wen Kong; Erik C. Dreaden; Sandra Morandell; Wen Zhou; Sanjeev S. Dhara; Ganapathy Sriram; Fred C. Lam; Jesse C. Patterson; Mohiuddin Quadir; Anh Dinh; Kevin E. Shopsowitz; Shohreh Varmeh; Ömer H. Yilmaz; Stephen J. Lippard; H. Christian Reinhardt; Michael T. Hemann; Paula T. Hammond; Michael B. Yaffe
Source
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Cell cycle checkpoint kinase, MK2, is in synthetic relationship with p53 in the DNA damage response to chemotherapeutic agents. Here, the authors report XPA as a third gene in which simultaneous targeting of MK2 and XPA further enhances sensitivity to cisplatin in p53-deficient tumours.