학술논문
Diagnostic and prognostic significance of circulating secreted frizzled‐related protein 5 in colorectal cancer
Document Type
article
Author
Source
Cancer Medicine, Vol 13, Iss 11, Pp n/a-n/a (2024)
Subject
Language
English
ISSN
2045-7634
Abstract
Abstract Background Secreted Frizzled‐Related Protein 5 (SFRP5) modulates Wnt signalling pathways, affecting diverse biological processes. We assessed the diagnostic and prognostic value of circulating SFRP5 (cSFRP5) in colorectal cancer (CRC) Methods Plasma cSFRP5 concentrations were measured using enzyme‐linked immunosorbent assay (ELISA) in healthy donors (n = 133), individuals diagnosed with CRC (n = 449), colorectal polyps (n = 85), and medical conditions in other organs including cancer, inflammation, and benign states (n = 64). Results Patients with CRC, polyps, and other conditions showed higher cSFRP5 levels than healthy individuals (p