학술논문
Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository (‘Registry’)
Document Type
article
Author
Vittorio Pengo; Ricard Cervera; Angela Tincani; Michelle Petri; Jane Salmon; Guillermo Ruiz-Irastorza; Savino Sciascia; Massimo Radin; Paul R Fortin; Pierluigi Meroni; Cecilia Nalli; Maria G Tektonidou; Laura Andreoli; Yu Zuo; Denis Wahl; Medha Barbhaiya; Olga Amengual; Hannah Cohen; Zhuoli Zhang; Guillermo Pons-Estel; Ignasi Rodríguez-Pintó; Rosario Lopez-Pedrera; Maria Gerosa; Bahar Artim-Esen; Maria Laura Bertolaccini; Ann Clarke; Roger Levy; D Ware Branch; LanLan Ji; Giulia Pazzola; Doruk Erkan; Rohan Willis; Jason Knight; Ecem Sevim; Robert Roubey; Michael Belmont; Ian Mackie; Leslie Skeith; Zeynep Belce Erton; Guilherme Ramires de Jesús; Amaia Ugarte; Danieli Andrade; Maria Angeles Aguirre- Zamorano; Michael Lockshin; Emilio Gonzalez; Cecilia B Chighizola; Gustavo Balbi; Stephane Zuily; Maria Efthymiou; Esther Rodgriguez Almaraz; Silvia Foddai; Nina Kello; Jose Pardos-Gea; Flavio Signorelli; Stacy Davis; Zhouli Zhang
Source
Lupus Science and Medicine, Vol 9, Iss 1 (2022)
Subject
Language
English
ISSN
2053-8790
Abstract
Objectives To describe the outcomes of pregnancies in antiphospholipid antibody (aPL)-positive patients since the inception of the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking Registry.Methods We identified persistently aPL-positive patients recorded as ‘pregnant’ during prospective follow-up, and defined ‘aPL-related outcome’ as a composite of: (1) Preterm live delivery (PTLD) at or before 37th week due to pre-eclampsia (PEC), eclampsia, small-for-gestational age (SGA) and/or placental insufficiency (PI); or (2) Otherwise unexplained fetal death after the 10th week of gestation. The primary objective was to describe the characteristics of patients with and without aPL-related composite outcomes based on their first observed pregnancies following registry recruitment.Results Of the 55 first pregnancies observed after registry recruitment among nulliparous and multiparous participants, 15 (27%) resulted in early pregnancy loss