학술논문
Association between high body mass index and prognosis of patients with early-stage breast cancer: A systematic review and meta-analysis
Document Type
article
Author
Source
Cancer Pathogenesis and Therapy, Vol 1, Iss 3, Pp 205-215 (2023)
Subject
Language
English
ISSN
2949-7132
Abstract
Background: A high body mass index (BMI) can indicate overweight or obesity and is a crucial risk factor for breast cancer survivors. However, the association between high BMI and prognosis in early-stage breast cancer (EBC) remains unclear. We aimed to assess the effects of high BMI on the prognosis of patients with EBC. Methods: The PubMed, Embase, and Cochrane Library databases and proceedings of major oncological conferences related to the effects of BMI on the prognosis of breast cancer were searched up to November 2021. Fixed- and random-effects models were used for meta-analyses. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) for disease-free survival (DFS) and overall survival (OS) were extracted from the included literature. Results: Twenty retrospective cohort studies with 33,836 patients with EBC were included. Overweight patients had worse DFS (HR: 1.16, 95% CI: 1.05–1.27, P = 0.002) and OS (HR: 1.20; 95% CI: 1.09–1.33, P