학술논문
Characteristics of different asthma phenotypes associated with cough: a prospective, multicenter survey in China
Document Type
article
Author
Jianmeng Zhou; Fang Yi; Feng Wu; Pusheng Xu; Meihua Chen; Huahao Shen; Lin Lin; Yunhui Zhang; Suyun Li; Changgui Wu; Yadong Yuan; Gang Wang; Xianwei Ye; Ping Zhang; Huaping Tang; Qianli Ma; Lanqing Huang; Zhongmin Qiu; Haiyan Deng; Chen Qiu; Guochao Shi; Jiayu Pan; Wei Luo; Kian Fan Chung; Nanshan Zhong; Kefang Lai; the CPA Cohort Study Group
Source
Respiratory Research, Vol 23, Iss 1, Pp 1-11 (2022)
Subject
Language
English
ISSN
1465-993X
Abstract
Abstract Background Asthma is a heterogeneous disease with variable symptoms, which presents with cough either as the sole or predominant symptom with or without wheezing. We compared the clinical and pathophysiological characteristics of cough predominant asthma (CPA), cough variant asthma (CVA) and classic asthma (CA) in order to determine any differential phenotypic traits. Methods In 20 clinics across China, a total of 2088 patients were finally recruited, including 327 CVA, 1041 CPA and 720 CA patients. We recorded cough and wheezing visual analogue scale, Leicester cough questionnaire (LCQ) and asthma control test scores. Fractional exhaled nitric oxide (FeNO), induced sputum cell counts, and capsaicin cough challenge were also measured and compared. Results CPA patients more frequently presented with cough as the initial symptom, and laryngeal symptoms (p