학술논문
SARS-CoV-2 variants and mutational patterns: relationship with risk of ventilator-associated pneumonia in critically ill COVID-19 patients in the era of dexamethasone
Document Type
article
Author
Keyvan Razazi; Anissa Martins Bexiga; Romain Arrestier; Bastien Peiffer; Guillaume Voiriot; Charles-Edouard Luyt; Tomas Urbina; Julien Mayaux; Tài Pham; Damien Roux; Raphael Bellaiche; Zakaria AIt Hamou; Stéphane Gaudry; Elie Azoulay; Armand Mekontso Dessap; Christophe Rodriguez; Jean-Michel Pawlotsky; Slim Fourati; Nicolas de Prost
Source
Scientific Reports, Vol 13, Iss 1, Pp 1-6 (2023)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract We aimed to explore the relationships between specific viral mutations/mutational patterns and ventilator-associated pneumonia (VAP) occurrence in COVID-19 patients admitted in intensive care units between October 1, 2020, and May 30, 2021. Full-length SARS-CoV-2 genomes were sequenced by means of next-generation sequencing. In this prospective multicentre cohort study, 259 patients were included. 222 patients (47%) had been infected with pre-existing ancestral variants, 116 (45%) with variant α, and 21 (8%) with other variants. 153 patients (59%) developed at least one VAP. There was no significant relationship between VAP occurrence and a specific SARS CoV-2 lineage/sublineage or mutational pattern.