학술논문
Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort study
Document Type
article
Author
Guillaume Martin-Blondel; François-Xavier Lescure; Lambert Assoumou; Charlotte Charpentier; Jean-Marc Chapplain; Thomas Perpoint; Gaspard Grouteau; Hugues Cordel; Gilles Pialoux; Jérome Pacanowski; Michael Thy; Adeline Bauvois; Didier Laureillard; Fadia Hamrouni; Michèle Algarte-Genin; Julien Poissy; Diane Descamps; Dominique Costagliola; for the CoCliCo Study Group
Source
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-9 (2022)
Subject
Language
English
ISSN
1471-2334
Abstract
Abstract Background The impact of the variant of concern (VOC) Alpha on the severity of COVID-19 has been debated. We report our analysis in France. Methods We conducted an exposed/unexposed cohort study with retrospective data collection, comparing patients infected by VOC Alpha to contemporaneous patients infected by historical lineages. Participants were matched on age (± 2.5 years), sex and region of hospitalization. The primary endpoint was the proportion of hospitalized participants with severe COVID-19, defined as a WHO-scale > 5 or by the need of a non-rebreather mask, occurring up to day 29 after admission. We used a logistic regression model stratified on each matched pair and accounting for factors known to be associated with the severity of the disease. Results We included 650 pairs of patients hospitalized between Jan 1, 2021, and Feb 28, 2021, in 47 hospitals. Median age was 70 years and 61.3% of participants were male. The proportion of participants with comorbidities was high in both groups (85.0% vs 90%, p = 0.004). Infection by VOC Alpha was associated with a higher odds of severe COVID-19 (41.7% vs 38.5%—aOR = 1.33 95% CI [1.03–1.72]). Conclusion Infection by the VOC Alpha was associated with a higher odds of severe COVID-19.