학술논문
Association between the metabolome and bone mineral density in a Chinese population
Document Type
article
Author
Source
EBioMedicine, Vol 62, Iss , Pp 103111- (2020)
Subject
Language
English
ISSN
2352-3964
Abstract
Background: Osteoporosis is a common metabolic bone disease, which always leads to osteoporotic fractures. Biomarkers of bone mineral density (BMD) are helpful for prevention and early diagnosis of osteoporosis. This study aims to identify metabolomic biomarkers of low BMD. Methods: We included 701 participants who had BMD measures by dual-energy X-ray absorptiometry scans and donated fasting plasma samples from three clinical centres as a discovery set and another 278 participants from the fourth centre as an independent replication set. We used a liquid chromatography-mass spectrometry-based metabolomics approach to profile the global metabolites of fasting plasma. Findings: Among the 265 named metabolites identified in our study, six were associated with low BMD (FDR-adjusted P