학술논문
Imaging response assessment for predicting outcomes after bioselection chemotherapy in larynx cancer: A secondary analysis of two prospective trials
Document Type
article
Author
Laila A. Gharzai; Julia Pakela; Elizabeth M. Jaworski; Issam El Naqa; Jennifer Shah; Peter G. Hawkins; Matthew E. Spector; Carol R. Bradford; Steven B. Chinn; Kelly Malloy; Robbi Kupfer; Andrew Shuman; Robert Morrison; Chaz L. Stucken; Andrew Rosko; Mark E. Prince; Keith Casper; Avraham Eisbruch; Gregory Wolf; Paul L. Swiecicki; Francis Worden; Michelle L. Mierzwa
Source
Clinical and Translational Radiation Oncology, Vol 33, Iss , Pp 30-36 (2022)
Subject
Language
English
ISSN
2405-6308
Abstract
Background and purpose: Bioselection with induction chemotherapy in larynx cancer is associated with excellent larynx preservation and disease-specific survival but requires visual inspection of the primary tumor. We retrospectively compare clinical and imaging response in bioselected patients to develop predictive models of surgeon-assessed response (SR), laryngectomy-free survival (LFS), and overall survival (OS) in bioselected patients. Materials and methods: In a secondary analysis of patients on two single-institution bioselection trials, model building used a regularized regression model (elastic-net) and applied nested cross-validation. Logistic regression-based model was used to predict SR and Cox proportional hazard-based models were used to predict LFS and OS. Results: In 115 patients with a median age of 57 years, most patients had supraglottic tumors (73.0%) and T3/T4 disease (94.8%). Definitive treatment was chemoradiation in 76.5% and laryngectomy in 23.5%. Change in primary tumor (OR = 5.78, p