학술논문
Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal
Document Type
article
Author
Ambroise D. Ahouidi; Mary A. Rodgers; Abdou Padane; Nafissatou Leye; Ana Olivo; Moustapha Mbow; Aminata Mboup; Papa Alassane Diaw; Aminata Dia; Barbara Harris; Yacine Amet Dia Padane; Gora Lo; Todd V. Meyer; Cyrille K. Diedhiou; Diabou Diagne; Ndeye Coumba Toure Kane; Gavin Cloherty; Souleymane Mboup
Source
Scientific Reports, Vol 11, Iss 1, Pp 1-4 (2021)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages that carry mutations in the spike gene are of concern for potential impact to treatment and prevention efforts. To monitor for new SARS-CoV-2 mutations, a panel of specimens were sequenced from both wave one (N = 96), and wave two (N = 117) of the pandemic in Senegal by whole genome next generation sequencing. Amongst these genomes, new combinations of SARS-CoV-2 spike mutations were identified, with E484K + N501T, L452R + N501Y, and L452M + S477N exclusively found in second wave specimens. These sequences are evidence of local diversification over the course of the pandemic and parallel evolution of escape mutations in different lineages.